Gut-Lumen Uricase × ABCG2 Genotype Stratification + Flux Model (comp-019)

Frozen analysis archived to ./etc/experiments/comp-019-gut-lumen-uricase-abcg2-genotype-stratification/wiki-archive.md (272 lines). This wiki stub remains so cross-references resolve and the page stays discoverable. Computational analyses are write-once artifacts; the daemon does not need to re-read them on every sweep, so the long content lives next to the experiment that produced it at etc/experiments/comp-019-gut-lumen-uricase-abcg2-genotype-stratification/.

There was a worry that the engineered-koji platform's whole therapeutic mechanism might only work in patients who carry a specific genetic variant — Q141K in the ABCG2 transporter — which is the #1 genetic risk factor for gout. About 25% of European-ancestry gout patients carry this variant; up to 50% of East-Asian-ancestry patients do. If the platform mechanism only worked in this subset, the addressable demographic would shrink dramatically and the trial design would have to change.

Where the analysis lives: - Full archived analysis: ./etc/experiments/comp-019-gut-lumen-uricase-abcg2-genotype-stratification/wiki-archive.md - Experiment directory (inputs, scripts, outputs): ./etc/experiments/comp-019-gut-lumen-uricase-abcg2-genotype-stratification/ - Computational experiments index: computational-experiments.md