Upstream Complement Modulator Leads (comp-018)¶

The useful question remains: which upstream complement nodes and materials expose testable weaknesses before C5a generation?

COMP-018 does not answer that question as a reproducible or validated sweep. Its script performed shallow schema counting over a hand-curated catalog. It did not rerun searches, verify primary evidence, enforce translation review, or validate tiers. Cross-assay rankings, record totals, dietary conclusions, chassis extrapolations, and engineering priorities are invalid. The COMP-018 tombstone is non-runnable; Git retains the retired catalog and narratives.

Research leads that remain open¶

Rosmarinic acid, luteolin, and Helicteres compounds: assay-specific complement leads. The candidate-specific CFH-dependence synthesis preserves the reverified premises and matched experiment; the former COMP-020 is quarantined legacy literature provenance. Reverify an exact source record before reuse and do not import a threshold verdict or universal rank.
Houttuynia cordata polysaccharides: exact material identity, inflammatory direction, exposure, and gout relevance remain load-bearing. See the Houttuynia evidence page.
C1-INH: exact-construct expression, folding, glycosylation dependence, stability, retained inhibition, and compartment access remain open. See the C1-INH evidence page.

Each lead advances through its own material, compartment, exposure, function, and falsification gates. A negative result kills only the tested material and configuration.

Refresh rule¶

A future upstream-complement scan must use the repository literature-scan workflow: retain exact queries and failures in a compact receipt, write scientific findings only to their evidence homes, verify load-bearing values against primary sources, complete required independent translations, and avoid ranking incomparable assays or materials.