ABCG2 Q141K Pharmacological-Chaperone Screen (comp-032)

Current status: superseded; do not use its ranking. The comp-032 heuristic embedded drug-class priors in its score, making its apparent separation of the CFTR cross-protein comparators tautological. It did not establish chaperone binding or rescue.

The current result is comp-047: the static docking configuration is inconclusive. Rosuvastatin is excluded by ABCG2 evidence; vorinostat is the sole marginal executable row but is not a docking-backed priority. The CFTR comparators do not validate sensitivity for ABCG2 chaperones. The earlier candidate set remains an unranked hypothesis inventory and must not guide a compound or compounding decision.

The reproducible comp-032 artifact remains under wiki/etc/experiments/; Git preserves the former interpretation.