Track: [Name]¶
1. Gout weakness¶
[Causal or operational weakness in gout. Link the canonical system map.]
2. Exploit hypothesis¶
[One falsifiable statement. Name the compartment, population, and expected effect.]
3. Proposed engineering¶
[Payload, modality, chassis or delivery route, and the reason each is necessary.]
4. Evidence by level¶
- Clinical Trial: [Directly relevant human evidence or none.]
- Animal Model: [Evidence or none.]
- In Vitro: [Evidence or none.]
- Computational: [Current exact-artifact COMP receipt or none.]
- Mechanistic Extrapolation: [Inference and its premises.]
5. Key assumptions¶
- [Assumption with a source anchor.]
6. Failure modes and safety constraints¶
- [Failure, consequence, and detection method.]
7. Cheapest discriminating experiment¶
[Smallest experiment that changes the decision. Link the protocol when defined.]
8. Pass / revise / kill criteria¶
- Pass: [Outcome.]
- Revise: [Outcome and allowed redirect.]
- Kill: [Outcome that stops this track.]
9. Status and next move¶
[Current state, unresolved gate, next action. Do not preserve a changelog here.]
10. What remains true if this track fails¶
[Reusable system knowledge, validated method, or surviving tracks.]
11. Research leads¶
Use only for a novel connection that is worth preserving but not ready for a committed falsification card. Research Conjecture is an epistemic status, not an evidence level.
Research conjecture — [short title]
Grounded premises: [Source-backed premises with evidence levels and provenance.]
Novel leap: [Exact untested connection; state that direct evidence is absent.]
Why it matters: [Upside if true.]
Discriminating observation: [Cheapest observation or experiment that advances, redirects, or kills the lead.]