comp-022 Top-25 Uricase Cassette Designs (concordance + composite)¶
N-of-4 concordance threshold: >= 3 (75%). 2421 candidates pass; 501 unique cassette designs after collapsing propeptide/nglyc modifiers.
| Rank | Promoter | Signal Peptide | Codon Variant | Scaffold | Propeptide | N-glyc | CAI | mRNA-5' | Chap. load | Prior | N-of-4 | Composite |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | PamyB | SPamyB_pro | 5p_softened | direct_3xAla_pts1blk | prop_none | nglyc_ablated | 0.915 | 0.733 | 0.00 | 1.020 | 4 | 0.912 |
| 2 | PamyB | SPamyB_pro | 5p_softened | direct_his6_pts1ok | prop_none | nglyc_ablated | 0.915 | 0.733 | 0.00 | 1.020 | 4 | 0.912 |
| 3 | PamyB | SPamyB | 5p_softened | direct_3xAla_pts1blk | prop_none | nglyc_ablated | 0.915 | 0.733 | 0.00 | 1.000 | 4 | 0.904 |
| 4 | PamyB | SPamyB | 5p_softened | direct_his6_pts1ok | prop_none | nglyc_ablated | 0.915 | 0.733 | 0.00 | 1.000 | 4 | 0.904 |
| 5 | PamyB | SPglaA_pro | 5p_softened | direct_3xAla_pts1blk | prop_none | nglyc_ablated | 0.915 | 0.733 | 0.00 | 1.000 | 4 | 0.904 |
| 6 | PamyB | SPglaA_pro | 5p_softened | direct_his6_pts1ok | prop_none | nglyc_ablated | 0.915 | 0.733 | 0.00 | 1.000 | 4 | 0.904 |
| 7 | PamyB | SPamyB_pro | 5p_softened | direct_natag_pts1ok | prop_native | nglyc_ablated | 0.915 | 0.733 | 0.25 | 1.020 | 4 | 0.900 |
| 8 | PamyB | SPamyB | 5p_softened | direct_natag_pts1ok | prop_native | nglyc_ablated | 0.915 | 0.733 | 0.25 | 1.000 | 4 | 0.893 |
| 9 | PamyB | SPglaA_pro | 5p_softened | direct_natag_pts1ok | prop_native | nglyc_ablated | 0.915 | 0.733 | 0.25 | 1.000 | 4 | 0.893 |
| 10 | PamyB | SPglaA | 5p_softened | direct_3xAla_pts1blk | prop_none | nglyc_ablated | 0.915 | 0.733 | 0.00 | 0.950 | 4 | 0.885 |
| 11 | PamyB | SPglaA | 5p_softened | direct_his6_pts1ok | prop_none | nglyc_ablated | 0.915 | 0.733 | 0.00 | 0.950 | 4 | 0.885 |
| 12 | PamyB | SPalpA_pro | 5p_softened | direct_3xAla_pts1blk | prop_none | nglyc_ablated | 0.915 | 0.733 | 0.00 | 0.920 | 4 | 0.874 |
| 13 | PamyB | SPalpA_pro | 5p_softened | direct_his6_pts1ok | prop_none | nglyc_ablated | 0.915 | 0.733 | 0.00 | 0.920 | 4 | 0.874 |
| 14 | PamyB | SPglaA | 5p_softened | direct_natag_pts1ok | prop_native | nglyc_ablated | 0.915 | 0.733 | 0.25 | 0.950 | 4 | 0.874 |
| 15 | PamyB | SPpepO_pro | 5p_softened | direct_3xAla_pts1blk | prop_none | nglyc_ablated | 0.915 | 0.733 | 0.00 | 0.900 | 4 | 0.866 |
| 16 | PamyB | SPpepO_pro | 5p_softened | direct_his6_pts1ok | prop_none | nglyc_ablated | 0.915 | 0.733 | 0.00 | 0.900 | 4 | 0.866 |
| 17 | PamyB | SPalpA_pro | 5p_softened | direct_natag_pts1ok | prop_native | nglyc_ablated | 0.915 | 0.733 | 0.25 | 0.920 | 4 | 0.862 |
| 18 | PamyB | SPalpA | 5p_softened | direct_3xAla_pts1blk | prop_none | nglyc_ablated | 0.915 | 0.733 | 0.00 | 0.880 | 4 | 0.859 |
| 19 | PamyB | SPalpA | 5p_softened | direct_his6_pts1ok | prop_none | nglyc_ablated | 0.915 | 0.733 | 0.00 | 0.880 | 4 | 0.859 |
| 20 | PamyB | SPpepO_pro | 5p_softened | direct_natag_pts1ok | prop_native | nglyc_ablated | 0.915 | 0.733 | 0.25 | 0.900 | 4 | 0.855 |
| 21 | PglaA | SPamyB_pro | 5p_softened | direct_3xAla_pts1blk | prop_none | nglyc_ablated | 0.915 | 0.733 | 0.00 | 0.867 | 4 | 0.854 |
| 22 | PglaA | SPamyB_pro | 5p_softened | direct_his6_pts1ok | prop_none | nglyc_ablated | 0.915 | 0.733 | 0.00 | 0.867 | 4 | 0.854 |
| 23 | PamyB | SPpepO | 5p_softened | direct_3xAla_pts1blk | prop_none | nglyc_ablated | 0.915 | 0.733 | 0.00 | 0.850 | 4 | 0.848 |
| 24 | PamyB | SPpepO | 5p_softened | direct_his6_pts1ok | prop_none | nglyc_ablated | 0.915 | 0.733 | 0.00 | 0.850 | 4 | 0.848 |
| 25 | PamyB | SPlipase_pro | 5p_softened | direct_3xAla_pts1blk | prop_none | nglyc_ablated | 0.915 | 0.733 | 0.00 | 0.850 | 4 | 0.848 |