{
  "comp": "comp-023",
  "gem": {
    "id": "iWV1314",
    "biomodels": "MODEL1507180056",
    "source": "Vongsangnak 2008, BMC Genomics PMID 18801187",
    "reactions": 2361,
    "metabolites": 1104,
    "genes": 1346,
    "compartments": [
      "Cytosol",
      "Peroxisome",
      "Extracellular",
      "Mitochondria"
    ]
  },
  "constants": {
    "glucose_uptake_mmol_gDW_h": 10.0,
    "cordycepin_demand_mmol_gDW_h": 0.018728440269596136,
    "cordycepin_titer_anchor_mg_L_day": 564.64,
    "cordycepin_titer_pmid": "38071331 (Jeennor 2023)",
    "lactoferrin_aa_demand_mmol_gDW_h": 0.03744039878630256,
    "uricase_aa_demand_mmol_gDW_h": 0.0028761904761904766,
    "carnosine_demand_mmol_gDW_h": 0.005,
    "panD_demand_mmol_gDW_h": 0.01,
    "biomass_density_gDW_L_assumed": 5.0
  },
  "scenarios": {
    "WT": {
      "scenario": "WT",
      "status": "optimal",
      "growth_h_inv": 17.678440597111003,
      "glucose_uptake_mmol_gDW_h": 10.0,
      "kojic_acid_flux_mmol_gDW_h": 0.0,
      "ergothioneine_flux_mmol_gDW_h": 0.0,
      "max_kojic_flux_mmol_gDW_h": 5.766666666666711,
      "max_egt_flux_mmol_gDW_h": 1.0984126984126963
    },
    "dual (uricase + Lf)": {
      "scenario": "dual (uricase + Lf)",
      "status": "optimal",
      "growth_h_inv": 17.674798860065003,
      "glucose_uptake_mmol_gDW_h": 10.0,
      "kojic_acid_flux_mmol_gDW_h": 0.0,
      "ergothioneine_flux_mmol_gDW_h": 0.0,
      "uricase_load_mmol_aa_gDW_h": 0.0028761904761904766,
      "lactoferrin_load_mmol_aa_gDW_h": 0.03744039878630256,
      "max_kojic_flux_mmol_gDW_h": 5.765478740416565,
      "max_egt_flux_mmol_gDW_h": 1.098186426746018
    },
    "+cns1-cns2 (triple, cordycepin arm)": {
      "scenario": "+cns1-cns2 (triple, cordycepin arm)",
      "status": "optimal",
      "growth_h_inv": 17.67537300391262,
      "glucose_uptake_mmol_gDW_h": 10.0,
      "kojic_acid_flux_mmol_gDW_h": 0.0,
      "ergothioneine_flux_mmol_gDW_h": 0.0,
      "cordycepin_flux_mmol_gDW_h": 0.018728440269596133,
      "uricase_load_mmol_aa_gDW_h": 0.0028761904761904766,
      "lactoferrin_load_mmol_aa_gDW_h": 0.03744039878630256,
      "max_kojic_flux_mmol_gDW_h": 5.765666024818881,
      "max_egt_flux_mmol_gDW_h": 1.0982220999655132
    },
    "+carnS+panD (triple, carnosine arm)": {
      "scenario": "+carnS+panD (triple, carnosine arm)",
      "status": "optimal",
      "growth_h_inv": 17.67445397719203,
      "glucose_uptake_mmol_gDW_h": 10.0,
      "kojic_acid_flux_mmol_gDW_h": 0.0,
      "ergothioneine_flux_mmol_gDW_h": 0.0,
      "carnosine_flux_mmol_gDW_h": 0.005,
      "uricase_load_mmol_aa_gDW_h": 0.0028761904761904766,
      "lactoferrin_load_mmol_aa_gDW_h": 0.03744039878630256,
      "max_kojic_flux_mmol_gDW_h": 5.765366240418286,
      "max_egt_flux_mmol_gDW_h": 1.0981649981749115
    },
    "+panD only": {
      "scenario": "+panD only",
      "status": "optimal",
      "growth_h_inv": 17.674645578788134,
      "glucose_uptake_mmol_gDW_h": 10.0,
      "kojic_acid_flux_mmol_gDW_h": 0.0,
      "ergothioneine_flux_mmol_gDW_h": 0.0,
      "uricase_load_mmol_aa_gDW_h": 0.0028761904761904766,
      "lactoferrin_load_mmol_aa_gDW_h": 0.03744039878630256,
      "max_kojic_flux_mmol_gDW_h": 5.765428740417143,
      "max_egt_flux_mmol_gDW_h": 1.098176902936608
    },
    "+cns1-cns2 stress 10x titer": {
      "scenario": "+cns1-cns2 stress 10x titer",
      "status": "optimal",
      "growth_h_inv": 17.68054029854099,
      "glucose_uptake_mmol_gDW_h": 10.0,
      "kojic_acid_flux_mmol_gDW_h": 0.0,
      "ergothioneine_flux_mmol_gDW_h": 0.0,
      "cordycepin_flux_mmol_gDW_h": 0.18728440269596133,
      "uricase_load_mmol_aa_gDW_h": 0.0028761904761904766,
      "lactoferrin_load_mmol_aa_gDW_h": 0.03744039878630256,
      "max_kojic_flux_mmol_gDW_h": 5.767351584443717,
      "max_egt_flux_mmol_gDW_h": 1.0985431589417005
    },
    "+cns1-cns2 stress 100x titer": {
      "scenario": "+cns1-cns2 stress 100x titer",
      "status": "optimal",
      "growth_h_inv": 17.730868965889066,
      "glucose_uptake_mmol_gDW_h": 10.0,
      "kojic_acid_flux_mmol_gDW_h": 0.0,
      "ergothioneine_flux_mmol_gDW_h": 0.0,
      "cordycepin_flux_mmol_gDW_h": 1.8728440269596138,
      "uricase_load_mmol_aa_gDW_h": 0.0028761904761904766,
      "lactoferrin_load_mmol_aa_gDW_h": 0.03744039878630256,
      "max_kojic_flux_mmol_gDW_h": 5.774842960552843,
      "max_egt_flux_mmol_gDW_h": 1.1100226189956548
    },
    "+cns1-cns2 stress 1000x titer": {
      "scenario": "+cns1-cns2 stress 1000x titer",
      "status": "optimal",
      "growth_h_inv": 15.864861137332307,
      "glucose_uptake_mmol_gDW_h": 10.0,
      "kojic_acid_flux_mmol_gDW_h": 0.0,
      "ergothioneine_flux_mmol_gDW_h": 0.0,
      "cordycepin_flux_mmol_gDW_h": 18.728440269596135,
      "uricase_load_mmol_aa_gDW_h": 0.0028761904761904766,
      "lactoferrin_load_mmol_aa_gDW_h": 0.03744039878630256,
      "max_kojic_flux_mmol_gDW_h": 5.235558257125907,
      "max_egt_flux_mmol_gDW_h": 1.1854094167077616
    },
    "+cns1-cns2 stress 10000x titer": {
      "scenario": "+cns1-cns2 stress 10000x titer",
      "status": "infeasible",
      "growth_h_inv": null,
      "glucose_uptake_mmol_gDW_h": null
    },
    "+cns1-cns2 stress 100000x titer": {
      "scenario": "+cns1-cns2 stress 100000x titer",
      "status": "infeasible",
      "growth_h_inv": null,
      "glucose_uptake_mmol_gDW_h": null
    }
  },
  "decision_table": [
    {
      "scenario": "dual (uricase + Lf)",
      "growth_h_inv": 17.674798860065003,
      "growth_penalty_vs_WT": 0.0002059987715542331,
      "max_kojic_mmol_gDW_h": 5.765478740416565,
      "kojic_yield_vs_dual": 1.0,
      "max_egt_mmol_gDW_h": 1.098186426746018,
      "egt_yield_vs_dual": 1.0,
      "cordycepin_mmol_gDW_h": null,
      "verdict": "GREEN"
    },
    {
      "scenario": "+cns1-cns2 (triple, cordycepin arm)",
      "growth_h_inv": 17.67537300391262,
      "growth_penalty_vs_WT": 0.00017352170750205466,
      "max_kojic_mmol_gDW_h": 5.765666024818881,
      "kojic_yield_vs_dual": 1.0000324837555992,
      "max_egt_mmol_gDW_h": 1.0982220999655132,
      "egt_yield_vs_dual": 1.0000324837556052,
      "cordycepin_mmol_gDW_h": 0.018728440269596133,
      "verdict": "GREEN"
    },
    {
      "scenario": "+carnS+panD (triple, carnosine arm)",
      "growth_h_inv": 17.67445397719203,
      "growth_penalty_vs_WT": 0.00022550744207743714,
      "max_kojic_mmol_gDW_h": 5.765366240418286,
      "kojic_yield_vs_dual": 0.9999804873101881,
      "max_egt_mmol_gDW_h": 1.0981649981749115,
      "egt_yield_vs_dual": 0.999980487310183,
      "cordycepin_mmol_gDW_h": null,
      "verdict": "GREEN"
    },
    {
      "scenario": "+panD only",
      "growth_h_inv": 17.674645578788134,
      "growth_penalty_vs_WT": 0.00021466929178634396,
      "max_kojic_mmol_gDW_h": 5.765428740417143,
      "kojic_yield_vs_dual": 0.9999913276933844,
      "max_egt_mmol_gDW_h": 1.098176902936608,
      "egt_yield_vs_dual": 0.9999913276933879,
      "cordycepin_mmol_gDW_h": null,
      "verdict": "GREEN"
    },
    {
      "scenario": "+cns1-cns2 stress 10x titer",
      "growth_h_inv": 17.68054029854099,
      "growth_penalty_vs_WT": -0.00011877186895830671,
      "max_kojic_mmol_gDW_h": 5.767351584443717,
      "kojic_yield_vs_dual": 1.0003248375566842,
      "max_egt_mmol_gDW_h": 1.0985431589417005,
      "egt_yield_vs_dual": 1.0003248375567158,
      "cordycepin_mmol_gDW_h": 0.18728440269596133,
      "verdict": "GREEN"
    },
    {
      "scenario": "+cns1-cns2 stress 100x titer",
      "growth_h_inv": 17.730868965889066,
      "growth_penalty_vs_WT": -0.002965667050216574,
      "max_kojic_mmol_gDW_h": 5.774842960552843,
      "kojic_yield_vs_dual": 1.001624187783511,
      "max_egt_mmol_gDW_h": 1.1100226189956548,
      "egt_yield_vs_dual": 1.0107779444012144,
      "cordycepin_mmol_gDW_h": 1.8728440269596138,
      "verdict": "GREEN"
    },
    {
      "scenario": "+cns1-cns2 stress 1000x titer",
      "growth_h_inv": 15.864861137332307,
      "growth_penalty_vs_WT": 0.10258707207891796,
      "max_kojic_mmol_gDW_h": 5.235558257125907,
      "kojic_yield_vs_dual": 0.9080873406789511,
      "max_egt_mmol_gDW_h": 1.1854094167077616,
      "egt_yield_vs_dual": 1.0794245747693219,
      "cordycepin_mmol_gDW_h": 18.728440269596135,
      "verdict": "RED"
    },
    {
      "scenario": "+cns1-cns2 stress 10000x titer",
      "growth_h_inv": null,
      "growth_penalty_vs_WT": null,
      "max_kojic_mmol_gDW_h": null,
      "kojic_yield_vs_dual": null,
      "max_egt_mmol_gDW_h": null,
      "egt_yield_vs_dual": null,
      "cordycepin_mmol_gDW_h": null,
      "verdict": "INFEASIBLE"
    },
    {
      "scenario": "+cns1-cns2 stress 100000x titer",
      "growth_h_inv": null,
      "growth_penalty_vs_WT": null,
      "max_kojic_mmol_gDW_h": null,
      "kojic_yield_vs_dual": null,
      "max_egt_mmol_gDW_h": null,
      "egt_yield_vs_dual": null,
      "cordycepin_mmol_gDW_h": null,
      "verdict": "INFEASIBLE"
    }
  ]
}